Monday June 9, 2014 0 comments
FORT COLLINS - Research at Colorado State University has revealed new links between tuberculosis and diabetes, providing evidence that TB becomes more deadly when it occurs with diabetes and showing - for the first time - that TB can trigger pre-diabetes.
The study was conducted by Randall Basaraba, post-doctoral fellow Brendan Podell and colleagues at CSU and was recently published in the American Journal of Pathology.
The researchers work in CSU's Metabolism of Infectious Diseases Laboratory and Mycobacteria Research Laboratories.
The global rate of diabetes is increasing exponentially, particularly in developing countries with a high incidence of TB.
"Projections for increases in diabetes are astronomical," said Basaraba, a professor in CSU's Department of Microbiology, Immunology and Pathology.
"One-third of the human population is infected with Mycobacterium tuberculosis - the bacteria that causes tuberculosis - so we can expect a dramatic increase in the number of individuals who have both TB and diabetes. There is a merging of two global epidemics that will affect millions of people each year."
Supported by grants from the American Diabetes Association and the National Institutes of Health, the research team aims to understand the progression of TB in diabetic patients and to test treatments to improve TB and diabetes control when the two diseases occur together.