Bolder BioTechnology awarded $593K to research radiation exposure

Tuesday July 23, 2019 0 comments Tags: Boulder, Bolder BioTechnology, George Cox

BOULDER -- Bolder BioTechnology, Inc. announced it received a two-year Small Business Innovation Research Grant totaling $593,507 from the National Institute of Allergy and Infectious Diseases (NIAID) of The National Institutes of Health (NIH).bolder-biotech-logo 

The grant is a joint research project between Bolder BioTechnology and Indiana University School of Medicine.  Lead Investigators for the grant are George Cox of Bolder BioTechnology, Inc. and Christie Orschell, Indiana University School of Medicine. 

The grant supports studies to understand the unique ability of combinations of Bolder BioTechnology's recombinant hematopoietic growth factors to improve survival when administered as late as 48 hours following lethal radiation exposure, a time when other therapies are ineffective. 

Receipt of the entire grant award is contingent upon the achievement of certain research milestones.

Acute Radiation Syndrome (ARS) is a collection of illnesses that occur following exposure to high doses of ionizing radiation within a short period of time, such as might occur following a nuclear power plant accident or detonation of a nuclear weapon.

Subjects acutely exposed to high dose radiation typically develop severe neutropenia (low numbers of neutrophils) and thrombocytopenia (low numbers of platelets) within days to weeks of exposure. Many subjects die during this time period from infections due to a lack of neutrophils or from uncontrolled bleeding due to a lack of platelets.