Friday March 16, 2018 0 comments
AURORA -- Pathways Bioscience LLC, a biomedical sciences company focused on discovering and developing small molecule drugs and dietary supplements that act on gene transcription pathways, today announced it received a Phase I Small Business Innovation Research (SBIR) grant from the National Institute on Aging (NIA).
The grant will enable Pathways to pursue research on one of its Nrf2 activating dietary supplements, PB125®, for study in aging-related changes in muscle proteostasis, the company said.
PB125 activates the Nuclear Factor, Erythroid 2-Like-2 (NFE2L2, also known as Nrf2) transcription factor pathway, which regulates the expression of a large group of cell protective and anti-inflammatory genes.
"We are happy to be collaborating with Drs. Karyn Hamilton and Ben Miller at Colorado State University with this funding from the National Institute on Aging to evaluate the effects of our Nrf2 activating dietary supplement PB125 on changes in muscle proteostasis that occur during aging," said Joe M. McCord, Pathways co-founder and scientific leader.
In the project entitled, “Supporting Healthy Aging with a Phytochemical Combination that Acts at Multiple Control Points in the Nrf2 Activation Pathway,” scientists at Pathways Bioscience are collaborating with Hamilton and Miller at Colorado State University’s Translational Research on Aging and Chronic Disease (TRACD) Laboratory in the Department of Health and Exercise Science.
Part of the research being conducted there focuses on examining the biological determinants of aging and approaches that might slow the aging process. They are examining the hypothesis that proteostatic mechanisms, which are used by the body for maintaining healthy and balanced turnover rates for cellular proteins, may play a key role in controlling the aging process and contribute to healthy aging.
“We are enthusiastic about working with Dr. McCord and Pathways Bioscience to investigate the effects of PB125 and Nrf2 activation on proteostasis and aging.” said Drs. Miller and Hamilton.
“Our past studies resulted in some promising discoveries that provided insight about the role Nrf2 activation may play in providing resistance to stresses associated with aging.”
“Maintaining proper balance between rates of new protein synthesis and the breakdown of old, damaged protein becomes crucial with advanced age,“ said Brooks M. Hybertson, Pathways president and CEO and principal investigator on the project.
“Our preliminary data with our PB125 dietary supplement suggest that it may be useful in maintaining or recovering the balance that contributes to optimal health.
“We are honored and grateful to receive this SBIR award from NIA to investigate the possible role of Nrf2 activation by PB125 in maintaining proteostasis and increasing healthspan.”